![]() The optimal range for PaCO2 values was identified between 30 and 38 mmHg. Association with the study endpoints for the identifies subgroups was analyzed using multivariate analysis. By correlations with the study endpoints, clinically relevant cutoffs for the 14-days mean values for the lowest and highest daily PaCO2 levels were defined by receiver operating characteristic curve analysis. The study endpoints were: delayed cerebral ischemia (DCI), need for decompressive craniectomy due to increased intracranial pressure > 20 mmHg refractory to conservative treatment and poor outcome at 6-months follow-up (modified Rankin scale > 2). Daily PaCO2 values from arterial blood gas measurements were recorded for up to 2 weeks after ictus. All patients of a single institution treated for aSAH over 13.5 years were included (n = 633). We aimed to analyze the effect of PaCO2 levels on the course and outcome of aSAH. In turn, both complications are related to poor outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). The partial pressure of carbon dioxide (PaCO2) in the arterial blood is a strong vasomodulator affecting cerebral blood flow and the risk of cerebral edema and ischemia after acute brain injury.
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